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Louisville at Clemson: Head to Head

Saturday Feb 28, 2026 2:00 pm - Clemson, SC
Odds: Louisville by 2.5, Total Points: 146.5

Matchup Menu: LOU @ CLEM

More Games From Feb 28, 2026

Head To Head (Since 1997 Season)

These teams have met 4 times in the last 3 seasons (with 2025-2026 counting as one of those three) and are tied with a record of 2-2.

Below is their head-to-head history back through the 1997 season, not just over the past three seasons.

Date	Winner	Winner H/A/N	Score	ATS Cover	O/U Result
02/28/26	Clemson	Home	80-75	Clemson +2.5	Over 146.5
03/14/25	Louisville	Neutral	76-73	Louisville +2.0	Over 141.5
01/07/25	Louisville	Home	74-64	Louisville -3.5	Under 147.0
01/30/24	Clemson	Home	70-64	Louisville +16.0	Under 149.5
02/18/23	Louisville	Home	83-73	Louisville +11.0	Over 140.5
01/11/23	Clemson	Home	83-70	Louisville +17.0	Over 136.5
02/19/22	Louisville	Home	70-61	Louisville +1.0	Under 136.5
01/27/21	Clemson	Home	54-50	Clemson -1.5	Under 130.0
02/15/20	Clemson	Home	77-62	Clemson +4.5	Over 130.0
01/25/20	Louisville	Home	80-62	Louisville -10.0	Over 130.5
02/16/19	Louisville	Home	56-55	Clemson +4.5	Under 132.0
01/06/18	Clemson	Home	74-69	Louisville +6.5	Over 139.0
01/19/17	Louisville	Home	92-60	Louisville -5.0	Over 136.5
01/10/16	Clemson	Home	66-62	Clemson +6.5	Under 129.5
01/07/15	Louisville	Home	58-52	Clemson +18.0	Under 126.5
03/20/06	Louisville	Home	74-68	Louisville -3.0	Over 139.0