of 299 · 4th in CONMEBOL
Projected roster. Final squads will be updated before the World Cup starts.
| Pos | Name | Detailed Pos | Club | League |
|---|---|---|---|---|
| GK | Sergio Rochet | Internacional | Brasileirão Série A | |
| GK | Fernando Muslera | Estudiantes de La Plata | Liga Profesional Argentina | |
| GK | Santiago Mele | CF Monterrey | Liga MX | |
| DEF | Guillermo Varela | Flamengo | Brasileirão Série A | |
| DEF | Ronald Araújo | FC Barcelona | La Liga | |
| DEF | José María Giménez | Atlético de Madrid | La Liga | |
| DEF | Santiago Bueno | Wolverhampton Wanderers | Premier League | |
| DEF | Sebastián Cáceres | Club América | Liga MX | |
| DEF | Mathías Olivera | Napoli | Serie A | |
| DEF | Joaquín Piquerez | Palmeiras | Brasileirão Série A | |
| DEF | Matías Viña | River Plate | Liga Profesional Argentina | |
| MID | Manuel Ugarte | Manchester United | Premier League | |
| MID | Emiliano Martínez | Palmeiras | Brasileirão Série A | |
| MID | Rodrigo Bentancur | Tottenham Hotspur | Premier League | |
| MID | Federico Valverde | Real Madrid | La Liga | |
| MID | Giorgian de Arrascaeta | Flamengo | Brasileirão Série A | |
| MID | Nicolás de la Cruz | Flamengo | Brasileirão Série A | |
| MID | Agustín Canobbio | Fluminense | Brasileirão Série A | |
| MID | Juan Manuel Sanabria | Real Salt Lake | MLS | |
| MID | Facundo Pellistri | Panathinaikos | Super League Greece | |
| MID | Maximiliano Araújo | Sporting CP | Primeira Liga | |
| MID | Brian Rodríguez | Club América | Liga MX | |
| MID | Rodrigo Zalazar | SC Braga | Primeira Liga | |
| FWD | Darwin Núñez | Al Hilal | Saudi Pro League | |
| FWD | Rodrigo Aguirre | Tigres UANL | Liga MX | |
| FWD | Federico Viñas | Real Oviedo | Segunda División |
