of 299 · 6th in CONMEBOL
Projected roster. Final squads will be updated before the World Cup starts.
| Pos | Name | Detailed Pos | Club | League |
|---|---|---|---|---|
| GK | Gatito Fernández | Cerro Porteño | División de Honor (Paraguay) | |
| GK | Orlando Gill | San Lorenzo | Liga Profesional de Fútbol (Argentina) | |
| GK | Gastón Olveira | Olimpia | División de Honor (Paraguay) | |
| DEF | Juan Cáceres | Dynamo Moscow | Russian Premier League | |
| DEF | Gustavo Gómez | Palmeiras | Campeonato Brasileiro Série A | |
| DEF | Gustavo Velázquez | Cerro Porteño | División de Honor (Paraguay) | |
| DEF | Fabián Balbuena | Grêmio | Campeonato Brasileiro Série A | |
| DEF | Júnior Alonso | Atlético Mineiro | Campeonato Brasileiro Série A | |
| DEF | Omar Alderete | Sunderland | EFL Championship | |
| DEF | José Canale | Lanús | Liga Profesional de Fútbol (Argentina) | |
| DEF | Alexandro Maidana | Talleres | Liga Profesional de Fútbol (Argentina) | |
| MID | Damián Bobadilla | São Paulo | Campeonato Brasileiro Série A | |
| MID | Andrés Cubas | Vancouver Whitecaps | Major League Soccer | |
| MID | Diego Gómez | Brighton & Hove Albion | Premier League | |
| MID | Matías Galarza | Atlanta United | Major League Soccer | |
| MID | Alejandro Romero Gamarra | Al Ain | UAE Pro League | |
| MID | Braian Ojeda | Orlando City | Major League Soccer | |
| MID | Maurício Magalhães | Palmeiras | Campeonato Brasileiro Série A | |
| FWD | Alex Arce | Independiente Rivadavia | Liga Profesional de Fútbol (Argentina) | |
| FWD | Miguel Almirón | Atlanta United | Major League Soccer | |
| FWD | Isidro Pitta | Red Bull Bragantino | Campeonato Brasileiro Série A | |
| FWD | Ramón Sosa | Palmeiras | Campeonato Brasileiro Série A | |
| FWD | Gabriel Ávalos | Independiente | Liga Profesional de Fútbol (Argentina) | |
| FWD | Antonio Sanabria | Cremonese | Serie B (Italy) | |
| FWD | Julio Enciso | Strasbourg | Ligue 1 | |
| FWD | Gustavo Caballero | Portsmouth | EFL Championship |
